| 摘要 |
2-Amino-6-substd.-9-(2,3-dideoxy -2-fluoro-beta-D-threopentofuranosyl) -9H-purine derivs. of formula (I) are new, where R is Cl, lower alkoxy, lower alkylthio or mono(lower alkyl)amino). Also new are intermediates of formula (II). Specifically claimed are 4 cpds. (I), including 2-amino-6-chloro-9-(2,3-di deoxy-2-fluoro-beta- D-threopentofuranosyl) -9H-purine and 2-amino-9-(2,3-dideoxy-2 -fluoro-beta- D-threopentofuranosyl -6-methylamino-9H-purine. Cpd. (II) is 2-amino-9-(5-0-benzoyl-2,3 -dideoxy-2-fluoro-beta-D -threopentofuranosyl)-6- chloro-9H-purine. (I; R = Cl) can be obtained by elimination of the aroyl group R1 from a 2-amino-9-(5-0-benzoyl-2,3 -dideoxy-2-fluoro-beta -D-threopentofuranosyl) -6-chloro-9H-purine of formula (II); where R2 is aroyl. |
