Latex particles in analytical reagents, elements and methods.

摘要

There is disclosed a method of making a latex comprising an aqueous phase having dispersed therein non-porous monodisperse surfactant-free polymeric particles having benzaldehyde groups on the surfaces thereof wherein the polymer particles comprise from 5 to 100 weight percent of recurring benzaldehyde units. The method comprises the step of reacting a polymer having recurring vinylbenzylic halide units with an alkali nitroalkanenitronate and an alkoxide in the presence of water and a water-miscible organic solvent. The polymeric particles of the latex are useful in immunoassays.