发明名称 A METHOD OF PRESERVING OPHTHALMIC SOLUTIONS AND COMPOSITIONS THEREFOR
摘要 Method of pressing an ophthalmic soln. comprises adding a source of a germicidally effective amt. of H2O2 and an effective amt. of H2O2-stabiliser. Pref. amt. of H2O2 produced is 0.001-0.10 wt.%, and this is the only preservative used. The H2O2 source is H2O2, sodium perborate decahydrate, sodium peroxide or urea peroxide. The stabiliser is 0.002-0.03 wt.% of diethylenetriamine penta (methylenephosphonic acid) or 0.005-0.2 wt.% of 1-hydroxyethylidene-1,1-diphosphonic acid, or their physiologically compatible salts. The soln. may also comprise 0.003-0.1 wt.% glycerin, and/or a toxicity agent: (buffers, NaCl, etc.) and/or an ophthalmically acceptable active ingredient which is comptabile with H2O2. Usual ophthalmic drugs may be used, provided they are H2O2-comptible. Amt. of H2O2 is reduced to less than 100 ppm, less than 60 ppm before contact with the eye.
申请公布号 ZA8905932(B) 申请公布日期 1990.03.28
申请号 ZA19890005932 申请日期 1989.08.03
申请人 CIBA-GEIGY AG 发明人 STEPHEN MERRITT MARTIN;FU-PAO TSAO
分类号 A61K9/08;A01N59/00;A61K8/00;A61K8/20;A61K8/22;A61K8/34;A61K8/40;A61K9/00;A61K31/66;A61K33/40;A61K47/04;A61K47/24;A61L;A61L2/18;A61L12/08;A61L12/12;A61P27/02;A61Q17/00;C07F9/141 主分类号 A61K9/08
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