OCTAHYDROINDOLO [2,3-A] QUINOLIZIN-1-YL- ALKANECARBOXYLIC ACID AMIDES AND THEIR THERAPEUTICALLY USEFUL ACID ADDITION SALTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME

摘要

23305-1034 OCTAHYDROINDOLO¢2,3-a!QUINOLIZIN-1-YL-ALKANECARBOXYLIC ACID AMIDES AND THEIR THERAPEUTICALLY USEFUL ACID ADDITION SALTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME A b s t r a c t The invention relates to new 1,2,3,4,6,7,12,12boctahydroindolo¢2,3,-a!quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I), (I) wherein R1 and R2 stand independently for a hydrogen or halogen atom, or a hydroxyl, nitro or C1-4 alkoxy group; R3 and R4 stand independently for a hydrogen atom or a C1-4 alkyl group; R5 and R6 stand independently for a hydrogen atom, C1-8 alkyl group, C3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl group containing oxygen, nitrogen or sulphur atom, all these groups being optionally substituted; or R5 and R6 together form an optionally substituted C2-8 .alpha., .omega.- alkylene group, wherein one carbon atom optionally be replaced by an oxygen or nitrogen atom; and G means a C1-4 straight chained alkylene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for preparing these compounds and compositions. The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.