摘要 |
<p>The invention relates to new compounds of the general Formula I /I/ and isomers thereof /wherein R1 is C1-10 alkyl, C3-6 cycloalkyl or phenyl, naphthyl or phenyl-/C1-4 alkyl/, wherein the aryl ring of the three latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C1-4 alkyl and/or C1-4 alkoxy substituent/s/; R2 stands for hydrogen, halogen, hydroxy, oxo, C1-4 alkyl, C1-4 aloxy, phenyl or naphthyl, wherein the two latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C1-4 alkyl and/or C1-4 alkoxy substituent/s/; R3 represents hydrogen, hydroxy or C1-4 alkoxy; Z is buta-1,3-dienyl or a group of the general Formula /a/ /a/ or /b/ /b/ and X is hydrogen or halogen. The compounds of the genreal Formula I posses useful pharmacological properties, particularly antidepressant and antiarrhythmial effect.</p> |
申请人 |
EGYT GYOGYSZERVEGYESZETI GYAR |
发明人 |
MESSMER, ANDRAS;BATORI, SANDOR;HAJOS, GYOERGY;BENKO, PAL;PALLOS, LASZLO;PETOCZ, LUJZA;GRASSER, KATALIN;SZIRT, ENIKOE NEE KISZELLY |