PROCESS FOR THE PREPARATION OF .beta.-LACTAM COMPOUNDS

摘要

The present invention provides a process for the substitution of an acylamino .beta.-lactam compound at the carbon atom carrying the acylamino group, which process comprises reacting the .beta.-lactam compound with an halogenating agent and a nucleophilic reagent; characterised in that the acylamino group has an acidic group on the carbon atom adjacent the carbonyl group. In particular the process of this invention comprises reacting a .beta.-lactam of partial structure (I): (I) where X represents an acidic group; with an halogenating agent and a nucleophilic reagent.