| 摘要 |
PURPOSE:To obtain a cell culture medium, excellent in adhesion and propagating properties of cells and capable of advantageously culturing the cells by forming a fine pattern having regularity on the surface of a substrate. CONSTITUTION:For example, a desired pattern is drawn on a substrate consisting of a polyacetal, polyamide or polystyrene, with ultraviolet rays, ionizing radiation, electron beams, ion beans or laser beams. Thereby, the substrate in the part irradiated with the beams is slightly deteriorated to form the pattern having surface energy different from that in the unirradiated part. Any pattern having the regularity can be formed as the pattern in this case and a pattern consisting of lines and spaces is especially preferred. The size of the pattern is especially preferably about 50Angstrom to 500mum. The depth thereof is normally suitably about 0.01-100mum. Cells can be stably adhered to the surface of the substrate and propagated for a long period by forming the above- mentioned pattern. |
