| 摘要 |
<p>A merozoite surface antigen of Plasmodium falciparum selected from the class characterised by: (i) having a relative molecular mass, Mr, (determined by SDS-polyacrylamide gel electrophoresis) in the range of approximately 41,000 to 53,000; and (ii) comprising multiple allelic forms of MSA2, having conserved N-terminal and C-terminal sequences; or an antigenic fragment thereof. Particular antigenic fragments include sequence corresponding to repeat sequences and sequences from conserved N-terminal and C-terminal regions. Production of antigens by recombinant DNA techniques as fusion and non-fusion proteins, and use in vaccine compositions is also disclosed.</p> |
