摘要 |
The invention relates to tetrahydronaphthalene and indane derivatives with the general formula I: <CHEM> wherein R<1> represents zero to four substituents, which may be the same or different and are selected from OH, halogen, NO2, CN, CF3, C1-C4 alkyl, C1-C4 alkoxy and unsubstituted or C1-C4 alkyl substituted amino; R<2> represents C1-C4 alkyl, C1-C4 alkenyl and C1-C4 alkynyl which may be substituted by halogen; R<3> and R<4> represent independently H, C1-C4 alkyl or form together with the nitrogen atom a 5- or 6-membered ring; n has the value 0 or 1; ALK is an aliphatic hydrocarbon with 1-8 carbon atoms and their pharmaceutically acceptable salts. These new compounds are typical monoamine reuptake blockers with additional alpha 2 antagonist activity and show strong anti-depressant activity without being sedative. Compounds according to this invention are also suitable for treating patients with anxiety disorders, e.g. panic disorder. |