Substituted pyridazinones.

摘要

Substituted benzylideneiminophenylpyridazinones or dihydropyridazinones of formula I <CHEM> in which R1 and R8 independently mean hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, trifluoromethyl, hydroxy alkyl, halogen alkyl, alkoxy alkyl, pyridyl, furyl, thienyl or cycloalkyl or one of optionally substituted groups; aryl, aralkyl, aralkenyl or nitrogen containing heterocyclic ring joining through an alkyl or alkenyl group and R3, R4 and R5 independently mean hydrogen, lower alkyl, hydroxy alkyl, halogen, hydroxy, alkoxy, acyloxy, aroyloxy, formyl, acyl, cyano, amino, carboxy or trifluoromethyl, R6 and R7 independently mean hydrogen, amino, lower alkyl, hydroxy, nitro or cyano or R2 and R7 together form a -CH2-NH- or -CH=N- group and A means phenyl, naphtyl or a nitrogen containing heterocyclic ring. The compounds may be used in the treatment of congestive heart failure.