| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is halomethyl or (amino-, lower alkoxy- or acylamino-substituted) arylthiomethyl; R<2> is lower alkoxy; R<3> is group of formula II or formula III; R<4> is alkylcarbamoyl, heterocyclic carbamoyl, etc.] or its salt. EXAMPLE:2-[2-(1-Chloromethyl-1-hydroxy-3-methoxy-4-morpholino- carbonyloxycyclohexyl)]-2-methyl-3-(3-methyl-2-butenyl)oxirane. USE:A drug. An arterialization inhibitor. Useful for the remedy of solid cancer, rheumatoid arthritis, retinopathy of diabetes mellitus, etc. PREPARATION:A compound of formula I wherein R<1> is -CH2 X can be produced by reacting a compound of formula IV with a compound of formula HX (X is halogen or R<1> excluding halomethyl) or its salt.
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