| 摘要 |
A process for preparing 1-methyllysergol or 10 alpha -methoxy-1-methyllumilysergol, which comprises adding a base, which is an alkali metal hydride or alcoholate, to a solution of lyergol or 10 alpha -methoxylumilysergol in a polar aprotic solvent in such a way that the molecular ratio between the base and the lysergol or 10 alpha -methoxylumilysergol remains less than 0.5:1, and then adding a methylating agent which is methyl iodide, methyl sulphate or trimethylsulphonium iodide. 1-methyllysergol and 10 alpha -methoxy-1-methyllysergol are useful intermediates in the synthesis of pharmacological compounds.
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