摘要 |
The method for preparing 4-amino-6, 7-dimethoxy-2-[4-(furo-2il)- piperazine-1-il -quinazoline (I) and its physiologically suitable salts comprises: (a) reacting 3,4-dimethoxy aniline with Ncyanodipheny limido carbonate to produce N"-cyano-N'- (3,4dimethoxyphenyl)-O-phenylisourea; (b) reacting the product of (a) with piperazine to produce piperazino-1-[N"-cyano-N'- (3,4dimethoxylphenyl) -carboxyimide amide; (c) cyclizing the obtained mixture to produce 4-amino-6,7-dimethoxy-2-piperazino quinazoline; (d) reacting salts obtained in step (c) with alkali to produce free base and then reacting free base with z-furan carboxylic acid chloride.
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