| 摘要 |
Title compounds I [X=O, S; R=A or B; Ar=phenyl, lower alkyl, alkoxy, thioalkoxy, halo, TFM, Het; Het=2-, 3-, or 4- pyridinyl, lower alkyl, alkoxy, et.! are prepared. Thus, a mixture containing 10mmol 7-(3- chloropropoxy)-4H-benzopyran-4-one, 11mmol 1-(2-chlorophenyl) piperazine dihydrochloride, 35mmol NaHCO3, and 0.6mmol NaI in 50ml dimethyl formamide is boiled at 85-90oC for 7 hrs. Solvent is evaporated and the organic layer is treated with 10% HCl-methanol solution. After evaporation, the resulting residure is recrystallized with ethanol/ethylacetate to give 3.2g 7-[3-(4-(2- chlorophenyl)-1-piperazinyl)propoxy!-4H-1-benzopyran4-one.
|
