| 摘要 |
Synthetic peptides which stimulate the release of pituitary GH in animals, including humans, and are more resistant to enzymatic degradation in the body than hGRF having the sequence: (B)R1-R2-R3-Ala-Ile-Phe-Thr-R8-Ser- THETA 10-Arg-R12-R13-Leu-R15-Gln-Leu-R18-Ala-A rg-R21-R22-Leu-R24-R @5-Ile-R27-R28-R @9-Gln-Gln-Gly-Glu-R34-Asn-Gln-Glu-R38-R39-R40-Arg-R42-R43-R44 wherein R1 is Tyr, D-Tyr, Met, D-Met, Phe, D-Phe, pCl-Phe, Leu, His or D-His; B is H, C<a>Me, N<a>Me, desamino, Ac or For; R2 is Ala, D-Ala, NMA or D-NMA; R3 is Asp or D-Asp; R8 is Ser, Asn, Lys, Arg, Asp or Gln; R10 is Tyr, D-Tyr or Phe; R12 is Arg or Lys; R13 is Ile, Val, Leu or Ala; R15 is Gly, Ala or beta -Ala; R18 is Ser or Tyr; R21 is Lys, D-Lys, Arg or D-Arg; R22 is Leu, Ile, Ala or Val; R24 is Gln or His; R25 is cys, abu, asp, glu, orn, lys, dab or dap; R27 is Met, D-Met, Ala, Nle, Ile, Leu, Nva or Val; R28 is Asn or Ser; R29 is cys, abu, asp, glu, orn, lys, dab or dap; R34 is Ser or Arg; R38 is Arg or Gln; R39 is Gly or Arg; R40 is Ala or Ser; R42 is Phe or Ala; R43 is Asn or Arg; R44 is a natural amino acid, such as Leu or Val. C-terminal sequences of from 1 to 15 residues beginning at R44 and extending as far as up to R29 may be deleted. These peptides as well as their nontoxic salts may also be used diagnostically. |
