| 摘要 |
<p>Enhanced magnetic resonance imaging contrast is provided by targeting paramagnetic material specifically to selected mammalian cell types. A carrier system for the paramagnetic material utilizes receptor mediated endocytosis to endow cell specificity and is formed by complexing the paramagnetic material to a glycoprotein-chelator conjugate. The conjugate is formed by bonding receptor-specific ligands to chelating agents through covalent bonding. The carrier not only exhibits a high degree of cell spcificity but also provides significant accumulation of the paramagnetic material within the cell to contribute to the improved enhancement of the magnetic resonance contrast.</p> |
