New silylating agent for the preparation of chromatographic supports.

摘要

A new mono-silylating agent of general formula (I) (R1,R2,R3)Si-NH-CO-O-Si(R1,R2,R3) (I) is described as well as its use in the preparation of chromatographic supports based on silica with functional groups covalently bonded thereto, the so-called "bonded stationary phases". The new compounds are easy and safe to prepare from the corresponding mono-halosilanes with ammonium carbamate, and their use as silylating agents leads to stationary phases with a higher degree of surface coating than that attainable with the corresponding chlorosilanes.