发明名称 |
TRYPTOPHAN PRODUCTION |
摘要 |
A multi-stage microbial process for the production of tryptophan is described where the biocatalyst production and bioconversion stages are separated. In the biocatalyst production stage bacterial host cells are transformed with a vector containing a DNA sequence coding for tryptophanase wherein the expression of the tryptophanase gene is directly controllable; the transformed host cells are induced to synthesise tryptophanase; and then in a subsequent bioconversion stage the reaction substrates for tryptophan synthesis are added and the tryptophan which accumulates in the reaction mixture is optionally isolated. |
申请公布号 |
AU4077589(A) |
申请公布日期 |
1990.03.05 |
申请号 |
AU19890040775 |
申请日期 |
1989.08.09 |
申请人 |
CELLTECH LIMITED |
发明人 |
STEPHEN JAMES FROUD;STEPHEN JOHN LITTLE;MARTYN KIM ROBINSON;GERALD LILLEY |
分类号 |
C12N1/20;C12N1/21;C12N9/88;C12N15/09;C12N15/60;C12P13/22;C12R1/19 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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