| 摘要 |
1-piparazinecarboxamide derivatives are described which have the formula (I) …<CHEM>… wherein R1 is a member selected from hydrogen, halogen or trifluoromethyl;… wherein X is selected from:… > CO (Ia)… > CHOH (Ib) > CHOR8 (Ib min ) > CHOCOR8 (Ib sec )… > CH2 (Ic)… > C = CR6R7 (Id)… > CH - CHR6R7 (Ie) …<CHEM>… wherein R2 and R3 are the same or different and selected from hydrogen or lower alkyl;… wherein Z ist either oxygen or sulfur;… wherein Y is -NR4R5, where R4 and R5 are the same or different and selected from hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aryl-(lower alkyl), or R4 and R5 may together with the N-atom form a 5- or 6- or 7-membered satin red ring, where one of the carbon atoms may be exchanged for O, NR8 or NCOR8;… wherein R6 and R7 are the same or different and selected from hydrogen or lower alkyl;… wherein R8 is lower alkyl or lower alkenyl;… with the proviso that when X is > CO, then R4 is hydrogen and R5 is different from hydrogen. …<??>Pharmaceutical compositions containing said 1-piperazinecarboxamide derivates are also described. …<??>The derivatives are useful in treating mental disorders and/or aggression in man and in treating aggression in animals and for calming animals. …<??>Different processes for preparing the derivatives are also described. |
