METHOD FOR PRODUCING NONHYPERGLYCOSYLATED HEPATITIS B VIRUS PROTEINS

摘要

The hepatitis B virus envelope proteins have been prepared in such a manner as to contain only polypeptide species in which the degree and nature of glycosylation is controlled and defined and in a such way that "hyperglycosylation" is eliminated. These proteins (and their component peptides) display the antigenic sites encoded by the S and preS domains of the HBV virion envelope open reading frame. Such proteins are useful for in vitro diagnostic systems and as vaccines for both the active and passive treatment or prevention of diseases and/or infections caused by the hepatitis B virus or other agents serologically related to the hepatitis B virus.