| 摘要 |
<p>PURPOSE:To prepare the titled compound useful as a synthetic intermediate of pharmaceuticals such as antiphlogistic agent, and a synthetic raw material of sweetener, etc., in high purity and yield, by reducing an optically active azide compound. CONSTITUTION:The objective compound of formula II can be prepared by reducing the novel optically active azide compound of formula I (R is H, cation or carboxyl-protecting group) in a solvent such as methanol, dioxane, tetrahydrofuran, etc., in a hydrogen atmosphere of atmospheric pressure-several atm (4- 5kg/cm<2>) using a metallic catalyst such as platinum, palladium nickel, etc. at 0- 50 deg.C. The reduction may be carried out using an alkali metal or alkaline earth metal salt such as sodium borohydride, etc. or using 1,3-propanedithiol.</p> |
