发明名称 |
PROCESS FOR THE PRODUCTION OF 1-ETHOXYCARBONYLOXYETHYL ESTER OF 6(D-(-)-ALPHA-AMINO-ALPHA-PHENYLACETAMIDO)PENICILLANIC ACID |
摘要 |
<p>???-Halogeno diethylcarbonate is used to prepare ethylcarbonyloxy- ethyl esters of penicillins and cephalo- sporins. The amino group in ampicillin can first be protected by reaction with an acetoacetate derivative and the protecting group removed after the esterification step. The new compound ???-bromo diethylcarbonate can be used without an esterification catalyst. The new compound is obtained by reacting acetaldehyde with carbonyl bromide followed by reaction with ethanol or by a halogen exchange reaction with the corresponding ???-chloro compound.</p> |
申请公布号 |
HK11190(A) |
申请公布日期 |
1990.02.23 |
申请号 |
HK19900000111 |
申请日期 |
1990.02.15 |
申请人 |
ASTRA LAKEMEDEL AKTIEBOLAG |
发明人 |
LUIGI RATTI;DEREK REGINALD PALMER;ROBERT GRAHAM TYSON |
分类号 |
C07C69/96;C07D499/00;C07D499/68;(IPC1-7):C07D499/44 |
主分类号 |
C07C69/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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