PEPTIDE DERIVATIVE AND ANTIDEMENT AGENT CONTAINING SAME DERIVATIVE

摘要

NEW MATERIAL:A peptide derivative (salt) expressed by formula I {A is Arg or Lys; Q<1> is H or pGlu; Q<2> is Gly-OH or OH; W is formula II [Y<1> is H or CO-T (T is formula III (R<1> is 2-7C alkylcarbonyl, 7-10C arylcarbonyl, etc.), etc.; Y<2> is OH or T; either of Y<1> and Y<2> includes T]}. USE:An antidement agent. PREPARATION:For example, a C-terminal amino acid having blocked carboxyl group is linked to an amino acid having protected alpha-amino group and functional groups in the side chain in DMF and the alpha-amino-protecting group is then removed. The above-mentioned operation is repeated to provide a peptide having formula IV (Z is benzyloxycarbonyl; MBzl is p-methoxybenzyl; Mbs is p- methoxybenzenesulfonyl). The resultant peptide is subsequently reacted with a compound expressed by the formula H-Cys(Scm)-T<1> (Scm is carbomethoxysulfenyl; T<1> is formula III, etc.) and the protecting groups are then removed to afford the compound expressed by formula I.