| 摘要 |
Compounds of general formula (I), wherein R1 is alkyl; alkenyl; alkynyl; tri(alkyl)silylethyl; optionally substituted aryl; mono- or di-halogenalkyl; phenylalkyl; a group of formula (II): R3-(CH2)n-S(O)m-CH2CH2- or formula (IIa): (R3-(CH2)n-S(O)m-CH2)2CH-CH2-, wherein R3 is H, carboxy, carboxyalkyl, hydroxy, amino, or a carrier, n is an integer from 1 to 24, and m is 0 or 2; a group of formula (III): Phe-S(O)m-CH2CH2- or formula (IIIa): (Phe-S(O)m-CH2)2CH-CH2- wherein each Ph is an optionally monosubstituted phenyl group; a group of formula (IV): R4CH2CH(CH2R5)CH2- wherein R4 and R5 independently are halogen; a group Q-(CH2)n- where Q is a carrier; and R2 is a mono- or disaccharide moiety connected via a glycosidic bond; alkyl; alkenyl; alkynyl; alkyloxymethyl; alkanoyl; alpha -hydroxy-alkanoyl; optionally substituted naphthyl-, heterocyclyl- or phenylalkoxy; a trialkylsilyl-containing group; halogen; omega -hydroxy-C1-4alkyl; tetrahydropyranyl; benzyloxymethyl; cycloalkyl; a monoterpenyl moiety; optionally monosubstituted benzoyl; the acyl residue of a naturally occurring amino acid; or a group of formula (V): R6-C(O)-N(R7)-CH(R8)-CH2-, wherein R6 is C1-4 alkyl; or optionally monosubstituted phenyl, R7 is H or C1-4 alkyl, and R8 is H, C1-4 alkyl, or hydroxy-C1-4 alkyl, Z is -O-, -S-, -SO2-, or -CH2-, X is -O-, -S-, -SO2-, -CH2-, or -NR3-, wherein R3 is H or is one of the meanings for R2 above, R3 and R1 optionally being connected to form a ring, and Y is -O- or -NR3- where R3 and R2 optionally are connected to form a ring. Compounds of general formula (I) have enhanced receptor binding properties to bacteria and are useful in inhibiting the binding of bacteria to mammalian cell surfaces. |
