| 摘要 |
PURPOSE:To readily obtain the subject compounds as a medicine having pharmacological actions such as analgesic action, antiphlogistic action and alleviation of fever in high yield with industrial advantage by reacting an alpha-phenylethyl alcohol derivative with CO in the presence of a catalyst using a specified solvent. CONSTITUTION:An alpha-phenylethyl alcohol derivative of formula I (R is H, alkyl, alkenyl or aryl) is reacted with CO in the presence of a catalyst such as rhodium iodide in a mixture solvent of a hydrocarbon such as hexane and alpha- phenylpropionic acid derivative, preferably at 60-100 deg.C, preferably under ordinary pressure-100kg/cm<2> CO to obtain the objective compound of formula II. As the mixture ratio of the above-mentioned solvents, for example the weight ratio of the alpha-phenylpropionic acid derivative/hexane is (1/30)-(1/8). The alpha- phenylpropionic acid derivative used as the solvent may be different from the objective compound obtained as the reaction product but the same compound as the reaction product is better considering purification, etc., after the reaction. |
