| 发明名称 |
Cytotoxic drug conjugates. |
| 摘要 |
<p>A series of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comprising a carbonyl at the antibody end, and an alkylidene hydrazide at the vinca end.</p> |
| 申请公布号 |
EP0354728(A2) |
申请公布日期 |
1990.02.14 |
| 申请号 |
EP19890307915 |
申请日期 |
1989.08.03 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
CULLINAN, GEORGE JOSEPH;LAGUZZA, BENNETT COLEMAN;SCOTT, WILLIAM LEONARD |
| 分类号 |
C12P21/08;A61K39/395;A61P35/00;A61K47/48;C07D519/04;C07K1/113;C07K14/00;C07K14/705;C07K16/00;C07K19/00 |
主分类号 |
C12P21/08 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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