| 摘要 |
NEW MATERIAL:A compound expressed by formula I or acid-added salt of said compound (for R<2a> and R<3a> are simultaneously H, -Xa-R<1a> is n-butyl, cyclohexyl or benzyl, etc.; R<2a> is H and -Xa-R<1a> is benzyl and R<3a> is methyl, or -Xa-R<1a> and R<3a> and simultaneously phenyl; R<3a> is H and -Xa-R<1a> and R<2a> are ethyl, -Xa-R<1a> and R<2a> are n-butyl, or -Xa-R<1a> is benzyl and R<2a>, etc.; etc.). EXAMPLE:1-amino-3-benzylguanidine. USE:Inhibitor of Maillard reaction. Useful for remedy of various complication of diabetes mellitus or disease induced by senescence, etc. PREPARATION:A compound expressed by formula II is reacted with a compound expressed by the formula R<3a>-NHNH2 in water or alkanol at room temperature, or a compound expressed by formula III is reacted with ammonia in water with refluxing in the presence of ammonium sulfate to obtain the compound expressed by formula I. |
