METHOD OF (Z)-2-(2-AMINO-4-THIAZOLYL)-2-(ESTERIFIED-CARBOXYIMINO)ACETIC ACID'S HETEROTHIOESTER PRODUCTION

摘要

NEW MATERIAL:A 1-sulfo-2-azetidinone derivative having (3S,4S)-coordination shown by the formula I (R<1> is H or alkyl; R<2> is H or ester residue), its salt or ester. EXAMPLE:Sodium (3S,4S)-cis-3[2-(2-amino-4-thiazolyl)-2-(Z)-(p-nitrobenzyloxycarbonylm ethoxyimino)acetamido]-4-carbamoyloxymethyl-2-azetidinone-1-sulfonate. USE:A remedy for microbisms. Showing strong antibacterial action on Gram-negative bacteria including Pseudomonas aeruginosa, extremely stable to beta-lactamase produced by bacteria. PROCESS:A compound shown by the formula II (R<3> is amino-protecting group) is sulfonated, and the protecting group is eliminated, and, if necessary, the ester residue is removed to give a compound shown by the formula I .