CYTOTOXIC AGENT AGAINST SPECIFIC VIRUS INFECTION

摘要

A chimeric gene directing the synthesis of hybrid recombinant fusion protein in a suitable expression vector has been constructed. The fusion protein possesses the property of selective cytotoxicity against specific virus-infected cells. A CD4(178)-PE40 hybrid fusion protein has been made for selectively killing HIV-infected cells. A recombinant, soluble, truncated form of CD4 containing the active binding site for human immunodeficiency virus is provided. Novel hybrid proteins containing human CD4 sequences linked to human immunoglobulin constant regions to inhibit HIV infection are described.