| 发明名称 |
NONGLYCOSYLATED HUMAN INTERLEUKIN-3 COMPOSITIONS |
| 摘要 |
The present invention provides a pharmaceutical composition comprising a recombinant human IL-3 protein analog, rhuIL-3(Asp<15>, Asp<70>) derived by yeast expression and having a biological activity of at least 3.0x10<7> units per milligram in a human bone marrow proliferation assay, and a binding affinity for human monocyte IL-3 receptors, expressed as an inhibition constant, of at least 2.0 x 10<10> M<-1>, and an endotoxin content of less than 1 ng per mg protein. |
| 申请公布号 |
WO9001039(A1) |
申请公布日期 |
1990.02.08 |
| 申请号 |
WO1989US02599 |
申请日期 |
1989.06.14 |
| 申请人 |
IMMUNEX CORPORATION |
发明人 |
ANDERSON, DIRK, M.;COSMAN, DAVID, J.;PRICE, VIRGINIA, L. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/17;A61K38/20;A61K39/395;A61P7/00;A61P37/04;C07K14/00;C07K14/52;C07K14/54;C12P21/02;C12R1/865;(IPC1-7):C07K13/00;A61K37/00 |
主分类号 |
C12N15/09 |
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