2-AMINO-4-SUBSTITUTED-5-HYDROXYPYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF PULMONARY ASTHMATIC, ALLERGIC, INFLAMMATORY OF GASTROINTESTINAL DISEASES

摘要

HYDROXY AND ALKOXY PYRIMIDINES 2-Amino-4-substituted-5-(hydroxy or alkoxy)pyrimidines, which may be 6-substituted, and derivatives thereof are inhibitors of leukotriene synthesis and are therefore useful for the treatment of pulmonary, inflammatory, allergic and cardiovascular diseases. The compounds are also cytoprotective and therefore useful in the treatment of peptic ulcers.