LOW MOLECULAR WEIGHT DERIVATIVES OF PROUROKINASE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

Low molecular weight derivatives of human prourokinase are provided which comprise at least the sequence from amino acid 163 to amino acid 411 of mature prourokinase in single chain configuration. In preferred cases, the sequences making up the kringle domain, the receptor binding domain or cell binding domain are missing. The derivatives may be made up into medicaments by admixture with a pharmaceutically acceptable carrier. Such medicaments show thrombolytic activity.