发明名称 |
Tissue plasminogen activator analogues. |
摘要 |
Tissue plasminogen activator (t-PA) analogues have at least one substitution in the growth factor (GF) domain that at least partially reduces hepatic receptor binding without substantially jeopardising physico-chemical stability in blood or fibrinolytic activity. This results in a longer plasma half life. Substitutions in the beta-sheet encompassing residues 63-72, especially at Leu 66 and/or Tyr 67 and/or Phe 68, are particularly preferred. |
申请公布号 |
EP0352904(A1) |
申请公布日期 |
1990.01.31 |
申请号 |
EP19890306372 |
申请日期 |
1989.06.23 |
申请人 |
BRITISH BIO-TECHNOLOGY LIMITED |
发明人 |
EDWARDS, RICHARD MARK;DAWSON, KEITH;FALLON, ANTHON;CRAIG, STEWART |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61P7/02;C07H21/04;C12N;C12N1/00;C12N5/10;C12N9/00;C12N9/64;C12N9/72;C12N15/58;C22B4/02;C22B4/06;C22C1/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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