| 摘要 |
PURPOSE:To obtain an intraocular tension regulator for instillation, containing mabuterol as an active ingredient, capable of exhibiting powerful intraocular hypotensive action and effective against intraocular hypertension and glaucoma. CONSTITUTION:The objective substance obtained by containing 4-amino-3- chloro-5-trifluoromethyl-alpha-[(tert-butyl-amino)methyl]benzyl alcohol (referred to as mabuterol) as an active ingredient and formulating a pharmaceutical according to a conventional method. A salt of the mabuterol is preferably used and dissolved in an aqueous solvent, such as water, physiological saline solution or phosphoric acid buffer solution, to prepare an instillation solution of an aqueous solution without pain and inconvenience for use. The amount of eye drop is 1X10<-6>-2.0mg/day expressed in terms of hydrochloride of the mabuterol which is the active ingredient 1-2 times a day. The regulator has no miotic action of pilocarpine instillation solution without a fear of contraindication of beta-receptor blockers for patients suffering from asthma and causing bradycardia.
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