| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I [R<1> represents (protected) amino; R<2> represents (protected) carboxy or lower alkanoyl; R<3> represents (protected) carboxy or COO<->; R<4> represents lower alkenyl, heterocyclic thio-lower alkyl, H or heteronio lower alkyl, provided that R<3> represents (protected) carboxy when R<4> represents lower alkenyl, H, etc., and R<3> represents COO<-> or protected carboxy when R<4> represents heteronio lower alkyl]. EXAMPLE:7-{2-(2-Aminothiazol-4-yl)-2-[(E)-2- ethoxycarbonylvinyloxyimino]acetamide}-3-vinyl-3-cephem-4-carboxylic acid (syn isomer). USE:A preventive and remedy for microbism. PREPARATION:A compound expressed by formula II is reacted with a compound expressed by the formula CHidenticalCR<2> to form a compound expressed by formula III, which is then subjected to a protection reaction of amino group, and, after deprotecting a carboxy-protecting group, reacted with a compound expressed by formula IV.</p> |
