IMPROVEMENT IN SEROTONIN ANTAGONIST

摘要

PURPOSE: To obtain a medicinal preparation which inhibits selectively 5-HT1 receptor by formulating a propanolamine compound or its salt thereto as an active ingredient. CONSTITUTION: This objective compound includes a compound of formula I [Ar is formulas II and III (R2 is H, a 1-4 C alkyl, trifluoromethyl, etc.; X is H, CN, 1-4 C alkyl, etc.); R1 is methyl; Z is a 4-10 C alkane, formula IV (G is a single bond and a 1-4 C alkylidene; (a) and (c) are each 1-5; (b) is 0-5, a+c>2), etc.] or its salt as an active ingredient and is formulated with usual medicinal carriers, diluents and vehicles and it is pharmaceutically manufactured by usual methods to obtain the objective compound. This compound can be prepared in forms of oral, rectal, percutaneous, subcutaneous, intravenous, intramuscular and intranasal administrations and it is administrated at a dosage of 0.5-30mg/kg a day as the active ingredient. This preparation is useful for treatments of obesity, blimia, depression, hypertension, senesence, amnesia, sexual functional disease, anxiety, schizophrenia, gastrointestinal injury, headache and cardiac vascular injury.