摘要 |
Novel pyrazine derivatives are disclosed. The compounds possess a potent platelet aggregation-inhibiting activity and are effective for preventing diseases caused by aggregation of the platelet, for example, myocardial infarction and cerebral thromobsis. Representative examples of the pyrazine derivatives includes 2,3-bis(p-chlorophenyl)-5-methylpyrazine, 2,3-bis(p-methoxyphenyl)-5-methylpyrazine, 2,3-diphenyl-5-benzylpyrazine, 2,3-diphenyl-5-(p-methoxybenzyl)pyrazine, 2,3-bis(p-methoxyphenyl)-5-isopropylpyrazine, 2,3-bis(p-methoxyphenyl)-5-(2-thienylmethyl)pyrazine and 2,3-bis(p-methoxyphenyl)-5,6-dimethylpyrazine. The pyrazine derivatives can be generally prepared by heating a benzil derivative and a 1,2-diaminoethane derivative to produce a dihydropyrazine derivative and heating the resulting compound with sulfur at 100 DEG -180 DEG C. |
申请人 |
TERUMO KABUSHIKI KAISHA TRADING AS TERUMO CORP., TOKIO/TOKYO, JP |
发明人 |
WAKABAYASHI, TOSHIO, TAMA-SHI TOKYO, JP;HASEGAWA, HIROKAZU, CHOFU-SHI TOKYO, JP;OHTA, AKIHIRO, EDOGAWA-KU TOKYO, JP |