发明名称 |
MULTIFUNCTIONAL THROMBO-RESISTANT COATINGS AND METHODS OF MANUFACTURE |
摘要 |
The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chains. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions. |
申请公布号 |
WO9000343(A2) |
申请公布日期 |
1990.01.25 |
申请号 |
WO1989US01853 |
申请日期 |
1989.05.01 |
申请人 |
CARDIOPULMONICS, INC. |
发明人 |
WINTERS, SUZANNE;SOLEN, KENNETH, A.;SANDERS, CLIFTON, G.;MORTENSEN, J., D.;BERRY, GAYLORD |
分类号 |
A61L33/10;A61L33/00;A61M1/16;A61M1/36;B01D67/00;B01D69/12;C12N11/06 |
主分类号 |
A61L33/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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