BRADYKININ ANTAGONISTIC PEPTIDES

摘要

The present invention involves nona- or larger bradykinin antagonist peptides characterized by the structure: H-L-Q-T-U-V-W-X-Y-Z-Arg-OH where certain amino acid residues of the nonapeptide hormone bradykinin or other substituted analogs of bradykinin are altered as follows: either position 2, position 3, or both consist of a L-acidic, L-amide or L-hydroxamate amino acid residue; position 7 consists of a D-aromatic amino acid residue; and position 4 preferably consists of a L-aliphatic or a D-cyclic amino acid residue.