发明名称 |
HEPATOBILIARY NMR CONTRAST AGENTS |
摘要 |
<p>A method of decreasing the NMR relaxation times (T1 or T2) of water protons in contact with a biological tissue, the method involving administering to a human patient an NMR contrast agent comprising a paramagnetic ion complexed with a chelating substance, the contrast agent being characterized in that it is capable of binding non-covalently and non-immunologically to a component of the tissue, and as a result of such binding is capable of enhancing relaxivity of the water protons by a factor of at least 2, compared to the relaxivity induced by the paramagnetic substance alone free in solution, and subjecting the patient to NMR imaging.</p> |
申请公布号 |
CA1264663(A) |
申请公布日期 |
1990.01.23 |
申请号 |
CA19860508749 |
申请日期 |
1986.05.08 |
申请人 |
GENERAL HOSPITAL CORPORATION (THE) |
发明人 |
LAUFFER, RANDALL B.;BRADY, THOMAS J. |
分类号 |
G01R33/28;A61B5/055;A61B10/00;A61K49/00;A61K49/06;(IPC1-7):A61B5/055 |
主分类号 |
G01R33/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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