| 摘要 |
4'-Deoxy-2'-halo-anthracycline antibiotics (I) are disclosed, as well as compositions including such antibiotics, and methods for their use in inhibiting neoplastic cell growth. Also disclosed are synthetic methods and intermediates which are useful in preparing such anthracyclines, as well as other previously unaccessible 4'-deoxy-2'-halo-3'-hydroxy anthracycline antibiotics, where R<1> is selected from the group consisting of CH3 and CH2OH, where R<2> is selected from the group consisting of H and acyl having the formula -COR<3> where R<3> is selected from the group consisting of aliphatic and aromatic hydrocarbons having 1-18 carbons, and where X is selected from the group consisting of F, Cl, Br, and I. |
