发明名称 |
PRODUCTION OF MEDICINE CONTAINING GONADORIBERIN DERIVATIVE AND USE THEREOF |
摘要 |
Pharmaceutical compositions for treating hormone-dependent tumours without inducing hormonal castration contain a gonadoliberin derivative of general formula (I), Gip-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4 (I) wherein X1 stands for a glycyl group or a D-isomer of any native or synthetic aromatic D-amino acid group; X2 stands for an L-amino acid group bearing a C1-4alkyl or L-phenylalanyl or L-tryptophyl group; X3 stands for an L-amino-acid residue bearing a C1-4alkyl or C2-4alkanoyl amide side chain; and X4 means a glycyl amide or C1-4alkyl amide group, with the proviso that X3 means a group different from leucyl when X2 stands for a tryptophyl group and X1 is other than glycyl group, its addition salts formed with pharmaceutically acceptable acids or metal complexes. |
申请公布号 |
JPH0215097(A) |
申请公布日期 |
1990.01.18 |
申请号 |
JP19890115265 |
申请日期 |
1989.05.10 |
申请人 |
INNOFINANCE ALTALANOS INNOVACIOS PENZINTEZET |
发明人 |
JIERUJI KEERI;ROBAATO AI NIKORUSON;ISHIYUTOWAAN TEPURAAN;TAMAASHIYU GUIYAASHIYU;ANIKOO HORUBUAATO;JIERUJI BEKEENIYUI NEEE MAYORU;BARAAZU SEEKE;AGUNESHIYU BAROFU;ORUSOIYA CHIYUKA |
分类号 |
A61K38/04;A61K38/09;A61P35/00;C07K7/06;C07K7/23;C07K14/575 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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