发明名称 |
MONOCLONAL ANTIBODIES CAPABLE OF RECOGNISING GANGLIOSIDES GQ1B AND GT1A |
摘要 |
A monoclonal antibody is disclosed that specifically recognizes an epitope or an antigenic determinant represented by the following formula and specifically reacts therewith: <CHEM> The monoclonal antibody can be obtained by cultivating hybridoma cells which can be generated by a method comprising fusing (A) B cells or lymphocytes obtained by immunizing an animal with a substance involving the epitope or the antigenic determinant represented by the foregoing formula with (B) myeloma cells. The monoclonal antibody shows a high specificity for ganglioside GQ1b and ganglioside GT1a having a specific epitope and thus can detect the epitope with a high sensitivity. Therefore, the antibody can be used for the elucidation of sugar chain's roles in cell functions and for studying the development of animals. Moreover, the monoclonal antibody has various clinical applications. |
申请公布号 |
AU3814489(A) |
申请公布日期 |
1990.01.18 |
申请号 |
AU19890038144 |
申请日期 |
1989.07.14 |
申请人 |
MECT CORPORATION |
发明人 |
YOSHITAKA NAGAI;HIDEKI YAMAMOTO;KINJI TAKADA;MASAYOSHI ITO |
分类号 |
G01N33/53;A61K39/395;C07K16/18;C12N5/10;C12N5/18;C12N5/20;C12N15/02;C12P21/08;C12R1/91;G01N33/577 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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