N-SUBSTITUTED-AMIDO-AMINO ACIDS

摘要

ABSTRACT OF THE DISCLOSURE
Compounds of the formula



wherein
R and R9 are independently hydroxy, lower alkoxy,
lower alkenoxy, di(lower alkyl)amino-lower alkoxy, hydroxy-
lower alkoxy, acylamino-lower alkoxy, acyloxy-lower alkoxy,
aryloxy, aryloxyl-lower alkoxy, amino, lower alkylamino,
di-lower alkylamino, hydroxyamino, or aryl-lower alkylamino,
R1, R2, R3, R4, R5, R7, and R8 are independently
alkyl, alkenyl or alkynyl containing up to 20 carbon atoms,
aryl or aryl-lower alkyl containing up to 12 carbon atoms,
heterocyclic or heterocyclic-lower alkyl containing up to
12 carbon atoms, or cycloalkyl or cycloalkyl alkyl containing
up to 20 carbon atoms.
R6 is heterocyclic or heterocyclic alkyl;
R2 and R3 taken together with the carbon and
nitrogen to which they are respectively attached and R3
and R5 taken together with the nitrogen and carbon to which
they are respectively attached form an N-heterocycle containing
from 3 to 5 carbon atoms or 2 to 4 carbon atoms and a sulfur
atom,
and wherein said alkyl, alkenyl, and alkynyl
groups can be substituted with hydroxy, lower alkoxy, thio,
lower alkylmercapto, amino, lower alklamino, di(lower alkyl)
amino, halogen, and nitro;
and salts thereof, especially salts with pharmaceutically
acceptable acids and bases.
The compounds possess hypertensive and antitensin convert-
ing enzyme inhibitory activity.