发明名称 |
Process for preparing hybridoma cells which produce tumor-specific monoclonal antibodies |
摘要 |
High-yielding hybridoma cell lines which secrete monoclonal antibodies capable of binding to tumor cells of one or more types, but not normal cells can be obtained more readily by fusing myeloma cells with antibody-forming cells isolated from an animal immunized with tumor antigens, which has previously been made immunological tolerant to normal cell antigens, comprising the total antigens, or at least a proportion of the total antigens, of the normal cells corresponding to the tumor cells chosen as the source of immunizing antigens.
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申请公布号 |
US4892934(A) |
申请公布日期 |
1990.01.09 |
申请号 |
US19880244601 |
申请日期 |
1988.09.14 |
申请人 |
KYOWA HAKKO KOGYO KABUSHIKI KAISHA |
发明人 |
YOSHIDA, HAJIME;HANAI, NOBUO |
分类号 |
G01N33/577;A61K39/395;C07K16/30;C12N15/02;C12P21/08 |
主分类号 |
G01N33/577 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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