| 摘要 |
PURPOSE:To advantageously obtain the subject compound which is a useful optically active synthetic intermediate for beta-lactam compounds having excellent antimicrobial activity in high selectivity and yield by reducing a beta-lactam compound using a sterically asymmetric ruthenium compound and reusable catalyst. CONSTITUTION:A beta-lactam compound expressed by formula II (Ru1 and R<2> are H or protecting group of hydroxyl group; R<3> is H or protecting group of amino group) is reduced in the presence of a sterically asymmetric ruthenium compound expressed by formula I (R<4>, R<5> and R<6> are same or different aryl group which may be substituted, straight or branched chain lower alkyl which may be substituted or 3-7C cycloalkyl which may be substituted) in an amount of preferably (1/100)-(1/500)mol based on 1mol compound expressed by formula I under 0-120atm, preferably 1-110atm to afford a compound expressed by formula III. Hydrogen pressure is preferably reduced to improve the beta/alpha selectivity. |
