MINI-PROINSULIN, ITS PREPARATION AND USE

摘要

A mini-proinsulin in which the A and B chains are linked by the amino acid Arg in place of the C chain has insulin activity and is suitable for producing medicaments for the treatment of diabetes mellitus. It can also be converted straightforwardly with trypsin into an insulin derivative whose B chain is extended by Arg. The latter can be converted with carboxypeptidase B into insulin. However, it is also possible and advantageous to convert the mini-proinsulin directly into insulin in a one-pot process.