NEW SUBSTITUTED SULPHONAMIDES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Compounds of the formula I …… in which R1 is a lower alkyl or alkenyl group with 1-6 C atoms, a cycloalkyl radical with 3-7 C atoms, an aralkyl, aralkenyl or aryl radical, where each aryl radical can be substituted one or more times by halogen, C1-C6-alkyl, C1-C6-alkoxy, hydroxyl, trifluoromethyl, cyano, nitro, amino, C1-C6-alkylamino, C2-C12-dialkylamino, C1-C6-acylamino, C1-C16-acyl, C1-C6-alkylsulphenyl, -sulphinyl and -sulphonyl or by azide, R2 is a hydrogen atom, a C1-C6-alkyl, an aralkyl, an aralkenyl or an acyl group, A and B are a saturated or unsaturated alkylene chain with 1-10 carbon atoms, which can be substituted one or more times by C1-C3-alkyl groups, where the total of the carbon atoms in chains A and B is not less than 4 but not more than 11, Q is oxygen, sulphur, a sulphonyl or a sulphinyl group, or an amino group …… where R2 has the above definition, Y is a free carboxyl group, an esterified carboxyl, a carbamoyl or hydroxymethyl or tetrazolyl, the pharmacologically tolerated salts and optical and E/Z isomers or mixtures thereof, process for the preparation thereof and pharmaceutical preparations containing these compounds, for the treatment of metabolic disorders and/or blood flow disturbances.