19-FLUORO-OR CYANO-21-HYDROXYPROGESTERONE DERIVATIVES USEFUL AS 19-HYDROXYLASE INHIBITORS

摘要

19-Fluoro- and cyano- substituted 21-hydroxyprogesterone derivatives and related compounds which are active as 19-hydroxylase inhibitors and useful as antihypertensive agents are described herein. The compounds are prepared using appropriate synthetic pathways which will vary according to the nature of the specific 19-substituted progesterone or related compound desired.