THIENODIAZEPINE COMPOUNDS AND THEIR MEDICINAL USE.

摘要

Thienodiazepine compounds represented by general formula (I) (wherein R<1> and R<2> may be the same or different and each represents hydrogen, halogen, alkyl or aralkyl or, when taken together, R<1> and R<2> form a ring, R<3> represents oxygen, R<4> represents hydrogen, alkyl, alkenyl or -(CH2)mCOOR<6> (wherein R<6> represents hydrogen, alkyl, alkenyl or aralkyl, and m represents an integer of 1 to 6), or R<3> and R<4> are bound to each other to form a group represented by =N-N=C(R<5>)- (wherein R<5> represents hydrogen, alkyl, alkenyl, aralkyl or -(CH2)n-COOR<7> (wherein R<7> represents hydrogen, alkyl, alkenyl or aralkyl, and n represents an integer of 1 to 6)), Ar and X may be the same or different and each represents aryl or heteroaryl, and p represents 0 or an integer of 1 to 6), salts thereof, and their medicinal use are disclosed. These compounds exhibit an antagonistic effect against cholecystokinin and gastrin and show a persistent action of depressing pancreatic enzymes and secretion of gastric acid, thus being useful as agents acting on central and peripheral nerves and agents for prophylaxis or treatment of pancreatic trouble or gastroenteric ulcer.